Fixolin 400 treats symptoms of asthma and chronic obstructive pulmonary disorder (COPD) by relaxing airway muscles, making breathing easier.
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Fixolin 400 contains Doxofylline, a Bronchodilator medication used to treat asthma and chronic obstructive pulmonary disease (COPD). It can also alleviate apnea and other respiratory conditions linked with bronchospasm.
During treatment with Fixolin 400, your doctor will regularly monitor your blood levels of doxofylline and adjust the dosage as necessary. It's advisable to limit your intake of caffeine-containing foods and beverages (such as coffee) while using Fixolin 400.
Before taking Fixolin 400, inform your doctor about any liver, kidney, or heart issues you may have. Additionally, disclose any history of hypertension, hyperthyroidism, stomach ulcers, or concurrent infections.
Fixolin 400 is not recommended for individuals with severe hypotension or heart problems (like myocardial infarction). It is also contraindicated in breastfeeding women.
It's uncertain whether consuming alcohol with Fixolin 400 is safe. Consulting your doctor is advisable.
Information regarding the safety of using Fixolin 400 during pregnancy is not available. Consulting your doctor is recommended.
Fixolin 400 is deemed safe during breastfeeding. Studies suggest it doesn't significantly pass into breast milk and is not harmful to the baby.
Fixolin 400 typically doesn't impair driving ability.
Limited information exists on using Fixolin 400 in patients with kidney disease. Consulting your doctor is advisable.
Limited information exists on using Fixolin 400 in patients with liver disease. Consulting your doctor is advisable.
Inhibition of phosphodiesterase activities, resulting in bronchodilating effects.
Nausea, vomiting, epigastric pain, irritability, tachycardia, etc.
Doxofylline is used in the treatment and prevention of chronic obstructive pulmonary disease.
Doxophylline is a new type of bronchodilator distinguished by its structural variance from Theophylline, featuring a dioxolane group at position 7. This compound selectively hinders phosphodiesterase 4, resulting in the relaxation of bronchial smooth muscle. Notably, unlike Theophylline, Doxophylline displays reduced affinities for adenosine A1 and A2 receptors, contributing to its enhanced safety profile. Additionally, Doxophylline has been observed to inhibit platelet-activating factor (PAF) and the generation of leukotriene production.
Fixolin should not be combined with other xanthine preparations. It is advised to moderate the intake of beverages and foods containing caffeine while using Fixolin. Caution should be exercised when administering Fixolin concurrently with ephedrine or other sympathomimetic drugs. The simultaneous use of certain medications such as erythromycin, TAO, lincomycin, clindamycin, allopurinol, cimetidine, influenza vaccine, and propranolol may decrease the hepatic clearance of xanthine derivatives, leading to elevated plasma levels of the drug. Phenytoin, along with other anticonvulsants and cigarette smoking, may increase the clearance of xanthine derivatives, resulting in a reduction of their plasma half-life. Adjustments to the dosage of the drug may be necessary in such cases.
Hypersensitivity to Doxofylline, acute myocardial infarction, hypotension, lactation.
Animal studies have indicated that the active component of Doxophylline does not disrupt pre and postnatal development. However, due to insufficient clinical data on the effects of the medication during pregnancy, its use should be assessed on a case-by-case basis, considering the risk-benefit ratio. Doxophylline is contraindicated during lactation.
Several factors can decrease the hepatic clearance of xanthine derivatives, leading to elevated plasma levels of the drug. These factors include age, congestive heart failure, chronic obstructive pulmonary disease, severe liver disease, concurrent infections, and the coadministration of certain medications such as erythromycin, lincomycin, clindamycin, allopurinol, cimetidine, influenza vaccine, and propranolol. In such cases, dose reduction may be necessary. Monitoring of blood drug levels is advised when factors affecting xanthine derivative clearance are present to ensure therapeutic levels are maintained.
Exercise caution when administering the product to patients with cardiac disease, hypertension, the elderly, severe hypoxemia, hyperthyroidism, chronic corpulmonale, congestive heart failure, liver disease, peptic ulcer, and renal impairment. Particularly, use caution in patients with congestive heart failure, as drug clearance is significantly slower, leading to prolonged high blood levels even after treatment cessation. There is no risk of addiction or dependence with this medication.
Keep in a dry place away from light and heat. Keep out of the reach of children. Fixolin should be used only on the prescription of a specialist physician.
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